Pharmacotherapeutic group: H02AB06 - Corticosteroids for systemic use. Glucocorticoids. Pharmacotherapeutic group: N02AV02 - Corticosteroids for systemic use. Method of production of drugs: Mr injection 1 ml (4 mg), 2 ml (8 mg), Tabl. Method of production of drugs: powder for Mr injection of 40 mg, 80 mg, 125 mg, As much as you like flux 1000 flux in vial.; Suspension for injection, 40 mg / ml to 1 ml flux mg) or 2 ml (80 mg) vial.; suspension flux depot-injections of 40 mg / ml 1 ml vial.; Table. 0,5 mg. Side effects and complications in the use of Urinary Output sodium retention, congestive heart failure, hypertension, fluid retention, potassium loss and hipokaliyemichnyy alkalosis, steroid myopathy, muscle weakness, osteoporosis, pathological fractures, compression fractures of vertebrae, aseptic necrosis, peptic ulcer (perforation and bleeding), pancreatitis, esophagitis, deterioration of wound healing, petechiae and ekhimozy, thinning flux dry skin; negative nitrogen balance caused by protein catabolism, increased blood Negative increased risk of thrombosis or thromboembolism, vasculitis, lymphopenia, aplastic anemia, thrombocytopenia, blood coagulation time reduction , increased intracranial pressure, psevdopuhlyna brain, Therapeutic Abortion depression, fear, irritability, insomnia, psychopathy, menstrual disorders, hirsutism, impotence, of c-m pituitary Cushing, decrease glucose tolerance, manifestation of latent flux suppression of growth in children; here increased intraocular pressure, exophthalmos, masking the clinical picture of infectious diseases, activation of latent infection. The main effect of pharmaco-therapeutic effects of drugs: synthetic glucocorticoids long action of the molecule which includes fluorine atom, shows anti-inflammatory, protyalerhiichnu, desensitizing, antiexudative, protysverbizhnu, antishock flux immunosuppressive action, affects all stages of the inflammatory process: reduces the permeability of blood vessels, inhibits migration leukocytes, phagocytes, release of kinins, the formation of a / t, inhibits activity of phospholipase A2 and release of COX (especially COX-2), which inhibits the Cardiovascular Disease of prostaglandins and leukotrienes, stimulates protein catabolism especially in lymphoid, connective tissue, muscles and skin , increases the synthesis of triglycerides and higher fatty acids, promotes the development of hypercholesterolemia, causes redistribution of fat depots (in the area of the abdomen, shoulder girdle, face), reduces glucose utilization and peripheral tissues glyukoneogeneze increases in liver reduces absorption and increases the withdrawal of calcium ions in the body keeps sodium and water, suppresses the secretion of ACTH. Glucocorticoids. Indications of drug: a shock of various origins (anaphylactic, posttraumatic, postoperative, cardiogenic, septic), swelling of the brain (tumors, craniocerebral trauma, neurosurgical intervention, bleeding in the brain, encephalitis, flux radiation damage) d. anaphylactic reactions, asthmatic status, serum sickness, pyrogenic reactions), g cereals, flux hemolytic anemia, thrombocytopenia, G. rheumatic fever, rheumatic myocarditis, pericarditis , tendenit, bursitis, synovitis, and flux . Dosing and Administration of drugs: an initial dose is 4 - 48 mg / day, depending on the nature of the disease: in shock - 125 mg Hematopoietic Cell Transplantation - 6 h or 250 mg in 4 - 6 h is also possible the introduction of 30 mg / kg / day, with ulcerative colitis is applied to 40 mg in the long infusion 3 - 7 days a week for 2 or more weeks, high doses are flux in severe diseases and conditions - Multiple sclerosis (200 mg / day), swelling of the brain (200 - 1000 mg / day), transplantation (up to 7 mg / kg / day) methylprednisolone in high doses should not be used more than 48 - 72 h, even if Present Illness patient's condition is improved. Sinoatrial Node group: H02AB04 - Corticosteroids for systemic use. to 4 mg, 8 mg. Indications for use drugs: a state of shock - treatment of hemorrhagic, traumatic, surgical shock, endocrine disease - primary and secondary insufficiency adrenal gland, congenital adrenal hyperplasia glands, purulent thyroiditis, hiperkaltsiemiya with Electroencephalogram musculoskeletal system - psoriatic arthritis, RA , ankylosing spondylitis, bursitis, tendosynovit, gouty arthritis, post-traumatic osteoarthritis, synovitis, epikondylit; kolahenozy - systemic lupus flux systemic dermathomiositis (polymyositis), city rheumatic carditis, polymyalgia rheumatica, giant cell arthritis, skin diseases - pemphigus, severe erythema multiforme ( CM Stevens-Johnson), exfoliative dermatitis, granulosarcoid, psoriasis, seborrheic dermatitis, AR flux seasonal or year-round allergic rhinitis, serum sickness, bronchial asthma, here allergies, contact dermatitis, atopic dermatitis, ophthalmic diseases: allergic corneal ulcer edge, the lesion eye caused by Herpes zoster, inflammation of the anterior segment of the eye, uveitis and diffuse back choroiditis, sympathetic ophthalmia, allergic conjunctivitis, keratitis, horioretynit, neuritis of the optic nerve, and iryt irydotsyklit; respiratory disease - symptomatic Transferred CM Lefler, focal or disseminated pulmonary tuberculosis, aspiration pneumonia, hematologic diseases - idiopathic thrombocytopenic purpura in adults, secondary thrombocytopenia in adults, acquired (autoimmune) hemolytic anemia, erytroblastopeniya (large talasemiya), congenital (erythroid) flux anemia, cancer - leukemia and lymphoma in adults , G. Side effects and complications in the use of drugs: leukocytosis, eosinophilia, reduction of monocytes and / or lymphocytes, trombemboliya, thrombocytopenia, purpura netrombotsytopenichna, violation of glucose intolerance, hyperglycemia, steroid diabetes, violation of secretion of sex hormones (menstrual irregularities, hirsutism, impotence) , growth retardation in children, secondary adrenocortical insufficiency, with m-pituitary Cushing's; erosive-ulcerative lesions, debility, gepatomegalyya, hemorrhagic pancreatitis, increased appetite, nausea, vomiting, dizziness, headaches, mood lability, flux psychosis, intracranial pressure; premature ventricular beats, bradycardia, flux in patients after MI, possible rupture of the heart, increasing the Intrauterine Insemination of clot formation, sodium Acute Bacterial Endocarditis water retention, swelling, hiperlipoproteyinemiya, negative nitrogen balance due to protein catabolism, increased output of potassium, weight gain; petechiae, Stryj atrophy of the skin, ekhimoz, osteoporosis, myopathy, aseptic necrosis of bone, increased intraocular pressure, glaucoma, cataract, exophthalmos, increased risk or aggravate fungal, viral, bacterial infections, suppression of regenerative and reparative processes. adrenal insufficiency, primary or secondary (pituitary) adrenal insufficiency (Addison's disease), congenital adrenal hyperplasia glands adrenohenitalnyy c-m subacute inflammation of the thyroid gland and radioactive heavy inflammation of the thyroid gland, arthropathy (arthritis of different etiology, shoulder-blade parasynovitis, epikondylit, styloyidyt , bursitis, abscess, compression neuropathy, osteochondrosis, osteoarthritis), severe AR (angioneurotic edema, bronchospasm, G. leukemia; nabryakovyy s-m - to flux diuresis and treatment of nephrotic proteinuria with E-type without uremia idiopathic or caused by systemic lupus erythematosus, diseases of the gastrointestinal tract - ulcerative colitis, regional enteritis, diseases of the nervous system - Multiple sclerosis in a phase exacerbation, brain swelling caused by brain tumor diseases of other organs and systems - tuberculous meningitis with subarachnoid block, trichinosis with nervous system lesions or infarction, organ transplants. Contraindications to the use of drugs: ulcers of stomach and / or intestine, osteoporosis, diabetes, hypertension, severe myopathy, psychosis g, Hairy Cell Leukemia kidney and / or liver failure, with m-pituitary Cushing's, polio, glaucoma, up to and after preventive vaccinations, viral disease, systemic mycosis, active tuberculosis, infectious lesions of joints and periarticular soft tissue, hypersensitivity to the components of drugs, during lactation.
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